Madhuri hails from a Marathi Brahmin family and was born in Mumbai to Shankar and Snehalata Dixit. She did her schooling at the Divine Child High School and her college happened in Mumbai University. She has qualified as a microbiologist. Not only that, she is a trained Kathak dancer and still pursues it. She made her debut in the film industry at the tender age of 17 years.
 
This was with the film titled Abodh. The film failed to click at the box office. However, Madhuri’s real shot to stardom happened in the year 1988 with the film Tezaab. She also got the nomination for the Filmfare Best Actress award that year. This was followed by yet another blockbuster in the year 1989 with the film Ram Lakhan. Interestingly, Madhuri paired with Anil Kapoor in both films.
 
From then on, there was no turning back as Madhuri was seen in some of the biggest hits like Dil, Saajan, Beta, Khalnayak, Hum Aapke Hain Kaun, Raja and others. She also made her presence felt in television by taking part in Kaun Banega Crorepati, Koffee With Karan, Nach Baliye, Jhalak Dikhla Jaa and others. She also hosted a show named Kahina Kahi Koi Hai.
 
Madhuri got married to Dr Shriram Nene in the year 1999 and moved to Denver, USA. She is blessed with two kids Arin and Raayan. After living in the US for a decade, Madhuri relocated to Mumbai in 2011. She also became the muse for the legendary painter M F Husain who came up with a series of her paintings. She has won several Filmfare awards for the best actress.